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Long-term outcome of patients with antiphospholipid syndrome who undergo percutaneous coronary intervention

Leor Perl1, Adi Netzer, Eldad Rechavia

  • 1Rabin Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 39 Jabotinsky St., Petah-Tikva 49100, Israel. leorperl@gmail.com

Cardiology
|June 23, 2012
PubMed

Insights

Patients with antiphospholipid antibody syndrome (APS) undergoing percutaneous coronary intervention (PCI) experience higher rates of revascularization and major adverse cardiac events. However, myocardial infarction and mortality rates remain similar compared to other PCI patients.

Area of Science:

  • Cardiology
  • Immunology
  • Vascular Medicine

Background:

  • Antiphospholipid antibody syndrome (APS) is associated with increased atherothrombotic risk.
  • Limited data exist on the outcomes of APS patients undergoing percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To evaluate the long-term clinical outcomes of patients with APS following PCI.
  • To compare APS patients undergoing PCI with matched control groups.

Main Methods:

  • Retrospective comparison of 19 APS patients who underwent PCI (2003-2008) with 380 matched PCI patients and 1,458 ST-elevation myocardial infarction patients treated with PCI.
  • Clinical outcomes assessed over a 6-month to 4-year follow-up period.

Main Results:

  • APS patients undergoing PCI had a higher incidence of acute coronary syndrome as the indication for the procedure.
  • One-year follow-up revealed significantly higher rates of target vessel revascularization in APS patients.
  • This led to increased rates of major adverse cardiac events in the APS group, with no significant differences in MI or mortality.

Conclusions:

  • APS patients undergoing PCI demonstrate poorer long-term clinical outcomes primarily due to increased revascularization needs.
  • Further research is necessary to elucidate the underlying mechanisms driving these adverse outcomes in APS patients post-PCI.
Abstract

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