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Updated: May 21, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Levodopa increases speed of alternating movements in Parkinson's disease patients
Thomas Müller1, Sören Peters, Ali Harati
1Department of Neurology, St. Josef Hospital Bochum, Gudrunstr. 56, 44791 Bochum, Germany. th.mueller@alexius.de
Abstract:
Disturbances of alternating movement execution are a characteristic clinical sign of patients with Parkinson's disease (PD). Objectives were to compare instrumentally measured diadochokinetic motion series carrying out before and 1 h after standardised levodopa intake and to correlate the device results with the respective rating scores of the PD patients. Maximum velocity and interval improved following levodopa application. The amplitude of motions did not differ between both assessment moments. Closer correlations between rating- and diadochokinesimeter outcomes appeared before levodopa intake.
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