Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Column Efficiency: Plate Theory

Column Efficiency: Plate Theory

Band broadening in a chromatography column is measured by its efficiency. This is determined by the number of theoretical plates (N). Theoretical plate theory states that a separation column consists of a continuous series of imaginary plates where solute equilibration occurs between stationary and mobile phases.
A higher number of theoretical plates signifies better column efficiency and improved separation capabilities. Plate height affects bandwidth and separation quality; it is inversely...

Dosage Regimen Designs: Nomograms and Tabulations

Dosage Regimen Designs: Nomograms and Tabulations

Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...

Methods of Medium Optimization

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...

Euler's Formula to Columns with Other End Conditions

Euler's Formula to Columns with Other End Conditions

Euler's formula is very important in the field of structural engineering, providing a foundation for understanding the critical loading conditions of pin-ended columns. This formula links the modulus of elasticity, the moment of inertia of the cross-section, and the column's length, offering a precise calculation of the critical load at which a column is prone to buckling.

Area Computation by the Alternative Coordinate Method

Area Computation by the Alternative Coordinate Method

The alternative coordinate method, also known as the Shoelace Formula, is a technique for determining the area of a traverse using Cartesian coordinates. This method relies on the sequential arrangement of x and y coordinates for each point of the shape, ensuring accuracy and ease of application.In this approach, each corner's x and y coordinates are listed as fractions, with the x-coordinate as the numerator and the y-coordinate as the denominator. These coordinates are arranged sequentially...

Column Efficiency: Rate Theory

Column Efficiency: Rate Theory

The rate theory of chromatography provides quantitative insight into the shapes and widths of elution bands. These bands are based on the random-walk mechanism governing molecular migration within a column. The Gaussian profile of chromatographic bands arises from the cumulative effect of random molecular motions as they progress through the column.
During elution, a solute molecule experiences numerous transitions between stationary and mobile phases, exhibiting irregular residence times in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PI3K/AKT/mTOR pathway and its related molecules participate in PROK1 silence-induced anti-tumor effects on pancreatic cancer.

Open life sciences·2023

Same author

Dynamics of bacterial community, metabolites profile and physicochemical characteristics during solid-state fermentation of soybean meal and corn mixed substrates inoculated with Bacillus pumilus and Limosilactobacillus fermentum.

Journal of the science of food and agriculture·2023

Same author

Quantification of cardiac iron in patients with thalassemia with 3-T MRI calibrated by 1.5-T MRI.

Acta radiologica (Stockholm, Sweden : 1987)·2023

Same author

Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis.

Journal of neurology·2023

Same author

Aneurysm wall enhancement, hemodynamics, and morphology of intracranial fusiform aneurysms.

Frontiers in aging neuroscience·2023

Same author

High-Strength Ductility Joining of Multicomponent Alloy to 304 Stainless Steel Using Laser Welding Technique.

Materials (Basel, Switzerland)·2023

Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026

Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026

Same journal

Corrigendum: Measured and Monte Carlo simulated electron backscatter to the monitor chamber for the varian TrueBeam linac (2016<i>Phys. Med. Biol</i>.<b>61</b>8779).

Physics in medicine and biology·2026

Same journal

Corrigendum: 3D range-modulator for scanned particle therapy: development, Monte Carlo simulations and experimental evaluation (2017<i>Phys. Med. Biol</i>.<b>62</b>7075).

Physics in medicine and biology·2026

Same journal

Recent progress in applications of computing to radiotherapy (ICCR 2016).

Physics in medicine and biology·2026

Same journal

Novel TMS coils designed using an inverse boundary element method.

Physics in medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

A new column-generation-based algorithm for VMAT treatment plan optimization.

Fei Peng¹, Xun Jia, Xuejun Gu

¹Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, MI 48109, USA. feipeng@umich.edu

Physics in Medicine and Biology

|June 23, 2012

Summary

This summary is machine-generated.

This study introduces a new algorithm for optimizing Volumetric Modulated Arc Therapy (VMAT) treatment plans. The method enhances efficiency, reducing treatment delivery time to approximately two minutes while maintaining plan quality.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Related Experiment Videos

Last Updated: May 21, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Area of Science:

Medical Physics
Radiation Oncology
Computational Optimization

Background:

Volumetric Modulated Arc Therapy (VMAT) is a sophisticated radiation therapy technique.
Optimizing VMAT plans is complex, requiring consideration of machine parameters and clinical objectives.
Existing methods may not fully account for dynamic machine constraints during treatment planning.

Purpose of the Study:

To develop and evaluate a novel algorithm for optimizing VMAT treatment plans.
To incorporate gantry speed, dose rate, and gantry speed change rate constraints into VMAT optimization.
To minimize treatment time while ensuring plan quality and adherence to machine limitations.

Main Methods:

A column-generation-based algorithm is proposed for VMAT plan optimization.
The algorithm iteratively selects apertures and optimizes their intensities.
It incorporates constraints on gantry speed, dose rate, and gantry speed change rate, alongside MLC constraints.
GPU implementation is utilized for accelerated optimization.

Main Results:

The algorithm generates high-quality VMAT plans meeting clinical dose-volume criteria.
Treatment plans are deliverable in approximately two minutes for prostate cancer cases.
Optimization of a VMAT plan is achieved within 25-55 seconds using GPU acceleration.

Conclusions:

The proposed algorithm effectively optimizes VMAT plans, balancing plan quality and delivery efficiency.
It successfully integrates dynamic machine constraints into the treatment planning process.
The method offers a significant reduction in treatment time and computational optimization duration.