Novel ionic liquid supported-multicomponent reaction toward chimeric bis-heterocycles
Chih-Hau Chen1, Chan-Yu Chen, Po-Tsung Lin
1Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300-10, Taiwan.
Abstract:
A novel multicomponent reaction between IL-anchored 2-aminobenzoimidazoles, aldehydes, and electron-deficient dienophiles has been explored. The strategy was utilized to develop a rapid parallel synthesis for novel bis-heterocyclic skeleton of benzimidazole-linked dihydropyrimidine on an ionic liquid support. This multicomponent reaction is compatible with a wide range of substrates and furnishes the new chimeric scaffolds with high purity and excellent yields. Use of the ionic liquid as a soluble support facilitates purification by simple precipitation along with advantages like high loading capacity, homogeneous reaction conditions, and monitoring of the reaction progress by conventional NMR spectroscopy.
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