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NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis
Xian-Lu Zhuo1, Jun-Jun Ling, Yan Zhou
1Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Genetic variations in N-acetyltransferase 2 (NAT2) may increase oral cancer risk in Asians. This meta-analysis found no overall association but suggested a link in specific ethnic groups.
Area of Science:
- Genetics
- Oncology
- Epidemiology
Background:
- N-acetyltransferase 2 (NAT2) polymorphisms are implicated in various cancer risks.
- Previous studies on NAT2 and oral carcinoma susceptibility have produced inconsistent findings.
Purpose of the Study:
- To conduct a systematic meta-analysis to precisely estimate the association between NAT2 polymorphisms and oral carcinoma risk.
- To investigate potential ethnic differences in this association.
Main Methods:
- A comprehensive literature search was performed for case-control studies published up to December 2011.
- Data from seven studies, comprising 1,379 cases and 1,868 controls, were extracted for meta-analysis.
- Subgroup analyses were conducted based on ethnicity.
Main Results:
- Overall meta-analysis revealed no significant association between NAT2 polymorphisms and oral carcinoma risk (OR: 1.04, 95% CI: 0.79-1.39).
- Subgroup analysis indicated a potential increased risk of oral cancer among slow acetylators in the Asian population (OR: 1.38, 95% CI: 1.04-1.82).
- No significant association was observed in Caucasian or Mixed race populations.
Conclusions:
- NAT2 polymorphisms do not appear to be a significant risk factor for oral carcinoma overall.
- However, NAT2 polymorphisms may represent a low-penetrant risk factor for oral carcinoma specifically in Asian populations.
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