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Related Concept Videos

Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

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Related Experiment Video

Updated: May 21, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Aneuploidy screening for embryo selection.

Elpida Fragouli1, Dagan Wells

  • 1Reprogenetics UK, Oxford OX4 2HW, United Kingdom. efragouli@hotmail.com

Seminars in Reproductive Medicine
|June 23, 2012
PubMed
Summary
This summary is machine-generated.

Preimplantation genetic screening (PGS) identifies chromosomally normal embryos for IVF, reducing miscarriage and birth defects. New PGS technologies show high accuracy and promising clinical results for infertility treatment.

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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Area of Science:

  • Reproductive biology
  • Human genetics
  • Assisted reproductive technology

Background:

  • Chromosome abnormalities in human oocytes and embryos are frequent, leading to implantation failure, miscarriage, and developmental issues like Down syndrome.
  • Aneuploidy in embryos negatively impacts both natural conception and assisted reproductive treatments, including in vitro fertilization (IVF).

Purpose of the Study:

  • To summarize data on the frequency and types of chromosomal abnormalities in oocytes and embryos.
  • To present clinical outcomes of preimplantation genetic screening (PGS) and discuss its role in embryo selection.
  • To describe new PGS technologies and their preliminary clinical data.

Main Methods:

  • Review of published and novel data on chromosomal abnormalities in oocytes and embryos at cleavage and blastocyst stages.
  • Analysis of clinical outcomes from studies utilizing PGS.
  • Description and validation of next-generation PGS methods: comparative genomic hybridization (CGH), microarrays (aCGH, SNP arrays), and quantitative polymerase chain reaction (qPCR).

Main Results:

  • Next-generation PGS methods (CGH, microarrays, qPCR) offer comprehensive chromosomal analysis with high accuracy.
  • Preliminary clinical data from these advanced PGS techniques are encouraging.
  • The use of PGS as an embryo selection tool remains a subject of ongoing discussion and research.

Conclusions:

  • Advances in genetics and embryology, particularly new PGS technologies, are set to revolutionize infertility treatment.
  • Accurate identification of chromosomally normal embryos through PGS can potentially improve IVF success rates.
  • Continued research and validation are essential to fully integrate advanced PGS into clinical practice for better patient outcomes.