Related Experiment Video
Updated: May 21, 2026
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
Published on: March 18, 2021
[Characteristic of microglial activation of hippocampus in experimental epileptic rats]
Hong Sun1, Hai-qin Wu, Gui-lian Zhang
1Department of Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, China. sunhongxjt@yahoo.cn
Objective:
To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats.
Methods:
Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats.
Results:
OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d.
Conclusion:
Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.
