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Related Experiment Video

Updated: May 21, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

Autophagy: an emerging immunological paradigm.

¹Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. vderetic@salud.unm.edu

Journal of Immunology (Baltimore, Md. : 1950)

|June 23, 2012

Summary

Autophagy, a cellular process, plays a crucial role in immunity by eliminating microbes and regulating inflammation. This review highlights its expanding functions in both innate and adaptive immunity.

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Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages

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Published on: May 24, 2019

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Last Updated: May 21, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

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Published on: July 21, 2017

Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages

Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages

Published on: May 24, 2019

Area of Science:

Cellular Biology
Immunology

Background:

Autophagy is a fundamental eukaryotic process involved in cytoplasmic homeostasis.
Recent research reveals significant immunological functions and interactions with the immune system.

Purpose of the Study:

To review the diverse roles of autophagy in innate and adaptive immunity and inflammation.
To explore autophagy's impact on immune cell functions and its implications in disease.

Main Methods:

Literature review of current research on autophagy and immunity.
Synthesis of findings on autophagy's mechanisms in immune processes.

Main Results:

Autophagy mediates cell-autonomous elimination of intracellular microbes.
It influences inflammasome activation, cytokine secretion (e.g., IL-1β), and Toll-like receptor (TLR) and Nod-like receptor (NLR) signaling.
Autophagy impacts antigen presentation, T cell repertoire selection, and T cell homeostasis.

Conclusions:

Autophagy is a critical immunological process with broad implications for immune system function.
Its dysregulation is implicated in chronic inflammatory and autoimmune diseases, representing a new immunological paradigm.