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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Adaptive Real-Time Closed-Loop Temperature Control for Ultrasound Hyperthermia Using Magnetic Resonance Thermometry.

L Sun1, C M Collins, J L Schiano

  • 1Department of Bioengineering, College of Engineering, The Pennsylvania State University, University Park, PA 16802.

Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering
|June 23, 2012
PubMed
Summary
This summary is machine-generated.

Novel MRI-guided adaptive controllers rapidly achieve therapeutic hyperthermia temperatures using ultrasound heating. These advanced systems adjust in real-time, overcoming variations in tissue properties for precise thermal disease treatment.

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Area of Science:

  • Biomedical Engineering
  • Medical Physics
  • Oncology

Background:

  • MR thermometry enables temperature feedback control for thermal disease treatment.
  • Ultrasound hyperthermia relies on proton resonance frequency (PRF) shift for precise temperature control.
  • Fixed gain controllers struggle with variable tissue properties and organ characteristics.

Purpose of the Study:

  • To develop and implement novel MRI-guided adaptive closed-loop controllers for rapid and precise ultrasound hyperthermia.
  • To investigate the efficacy of self-tuning regulator (STR) and model reference adaptive control (MRAC) methods in real-time MR thermometry.
  • To overcome limitations of fixed gain controllers in achieving target therapeutic temperatures.

Main Methods:

  • Real-time, online MR thermometry was used to guide adaptive control strategies.
  • Self-tuning regulator (STR) and model reference adaptive control (MRAC) were implemented to adjust ultrasound array power.
  • Ex vivo (bovine muscle) and in vivo (rabbit thigh muscle, canine prostate) experiments were conducted.

Main Results:

  • Ex vivo experiments showed a 8 ± 1.37°C temperature increase in 6 ± 0.2 minutes.
  • In vivo rabbit muscle experiments reached 44.5°C ± 1.2°C in 8.0 ± 0.5 minutes.
  • Canine prostate hyperthermia achieved 43°C ± 2°C in 6.5 ± 0.5 minutes.

Conclusions:

  • Adaptive controllers with MR thermometry effectively track target temperatures despite dynamic tissue properties.
  • These novel controllers enable rapid achievement and management of therapeutic temperatures for hyperthermia.
  • The study demonstrates the potential of MRI-guided adaptive control for precise thermal disease treatment.