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Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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Related Experiment Video

Updated: May 21, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

The Purpose in Chronic Addiction.

Hanna Pickard1

  • 1Oxford Centre for Neuroethics, University of Oxford, and Oxford Health NHS Foundation Trust.

AJOB Neuroscience
|June 23, 2012
PubMed
Summary

Addiction is not a chronic disease but a chosen behavior, often resolving by age 30. Substance use may serve a purpose, particularly for individuals with co-occurring psychiatric disorders, suggesting a need for revised treatment approaches.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • The prevailing view defines addiction as a chronic, relapsing neurobiological disease.
  • National survey data indicate substance dependence rates peak in adolescence and early adulthood, declining thereafter.
  • Individuals with co-occurring psychiatric disorders present different patterns of substance use and relapse.

Purpose of the Study:

  • To challenge the neurobiological disease model of addiction.
  • To propose an alternative explanation for addiction as purposive action, particularly in comorbid psychiatric populations.
  • To identify factors contributing to addiction as a chosen behavior.

Main Methods:

  • Analysis of large-scale national survey data on substance dependence.

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Last Updated: May 21, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

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  • Hypothesizing the functional role of substance use in alleviating psychological distress for psychiatric patients.
  • Delineation of five folk psychological factors explaining addiction.
  • Main Results:

    • Substance dependence rates naturally decline in individuals without comorbid psychiatric disorders, suggesting "maturing out".
    • Substance use may serve the rational purpose of alleviating psychological distress in patients with comorbid conditions.
    • Addiction can be explained by factors such as desire, willpower, motivation, functional role, and decision-making.

    Conclusions:

    • The neurobiological disease model of addiction may be misguided.
    • Addiction can be understood as a chosen, purposive action rather than solely a compulsive disease.
    • Findings suggest a need for revised research and effective treatment strategies for addiction.