[Prognostic factors of primary spinal tumors]

Primary spinal tumors are rare diseases and there are less objective data in the international literature. We analyzed the epidemiology and clinical consequences of primary spinal tumors based on the clinical experience of the National Center for Spinal Disorders.

Demographic and clinical data of 300 patients treated in our institute between 1995 and 2007 was collected retrospectively and analysed.

Beyond the relatively more frequent pathologies (chordoma, myeloma multiplex) we treated in our hospital some of the very rare types of tumors (spinal leiomyosarcoma, synovial sarcoma). Primary spinal tumors are most often located in the lumbosacral region causing most frequently (73%) local or radiating pain. Modern therapy of these patologies is based on the surgical intervention. Mean operation time was 130 minutes, mean blood loss was 650 ml in our pratice during these often technically challenging surgeries. We found a significant association among the operation time, the blood loss and the extension of the tumor (p < 0.01). Histology (p < 0.0001), severity of symptomes (p < 0.05) and blood loss (p < 0.05) were significantly related to mortality. Local recurrence was more than 5-fold in case of patients previously operated in another institute (p < 0.0001).

We successfully determined some significant prognostic factor on clinical behavior of primary spinal tumors performing a large scale retrospective study. Long time follow up of the patients and completion of our database with prospective data are planned for the future.