Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 21, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging.

Haiyan Zhang1, Jianzhong Lin, Yingchun Sun

  • 1Department of Physiology and Neurobiology, Medical College of Xiamen University, Xiamen, China.

High Altitude Medicine & Biology
|June 26, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroprotective Dihydro-β-agarofuran-Type Sesquiterpenes from the Seeds of <i>Euonymus maackii</i>.

Journal of natural products·2019
Same author

Establishment of a human iPSC line (SDQLCHi010-A) from a patient with optic nerve malformation carrying a heterozygous mutation in PAX6 gene.

Stem cell research·2019
Same author

An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene.

Stem cell research·2019
Same author

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.

Cancer discovery·2019
Same author

Generation of an iPSC line (SDQLCHi015-A) from peripheral blood mononuclear cells of a patient with mental retardation type 15 carrying c.1007_1011del, p.(Ile336fs) in CUL4B gene.

Stem cell research·2019
Same author

Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.

Fitoterapia·2019

Short-term mountain climbing at high altitudes caused significant microstructural damage in the brain's white matter (WM), affecting fiber integrity. Cognitive tests showed no changes, but WM alterations may explain previous motor and cognitive deficits.

Area of Science:

  • Neuroscience
  • High-altitude physiology
  • Medical imaging

Background:

  • High-altitude exposure can impact physiological and cognitive functions.
  • Previous studies suggest potential neurological effects of climbing, but microstructural changes remain unclear.

Purpose of the Study:

  • To investigate cerebral microstructural alterations in mountaineers after short-term high-altitude climbing.
  • To assess changes in gray matter (GM) and white matter (WM) volumes and WM integrity using MRI.

Main Methods:

  • Voxel-based morphometry (VBM) and Tract-Based Spatial Statistics (TBSS) MRI analyses were performed on 14 climbers before and after ascent to 6206m.
  • Diffusion tensor imaging metrics, including fractional anisotropy (FA) and radial diffusivity, were evaluated.
  • Cognitive tests (verbal/spatial two-back, serial reaction time) were administered.

More Related Videos

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

Related Experiment Videos

Last Updated: May 21, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

Main Results:

  • No significant changes were observed in total or regional GM, WM, or cerebrospinal fluid volumes.
  • Significant decreases in FA were detected in multiple WM tracts, including the corticospinal tract, corpus callosum, and cerebellar peduncle.
  • Radial diffusivity tended to increase in affected WM regions, indicating microstructural damage.

Conclusions:

  • Short-term high-altitude climbing induces microstructural disturbances in cerebral white matter, compromising fiber integrity.
  • These WM alterations may underlie previously observed cognitive and motor deficits at high altitudes.
  • Further research is needed to understand the long-term implications of these findings.