Hepatitis B virus genotypes in eastern Azerbaijan, Northwest Iran

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Updated: May 21, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Leila Mohammadnejad1, Safar Farajnia, Kazem Parivar

  • 1Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Archives of Iranian Medicine
|June 26, 2012
PubMed

Insights

Hepatitis B virus (HBV) genotype D is the sole genotype found in Eastern Azerbaijan Province, Iran. This study found no link between HBV genotype D and infection types in the region.

Area of Science:

  • Hepatology
  • Virology
  • Molecular Biology

Background:

  • Hepatitis B virus (HBV) infection is a global health concern.
  • Genotyping of HBV is crucial for understanding its epidemiology and treatment.
  • Eastern Azerbaijan Province, Iran, lacked previous HBV genotype investigations.

Purpose of the Study:

  • To determine the HBV genotype distribution in hepatitis patients in Eastern Azerbaijan Province.
  • To provide the first report on HBV genotypes in this specific Iranian region.

Main Methods:

  • 100 HBV-infected patients were recruited.
  • Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg) status were assessed.
  • Polymerase chain reaction (PCR) with type-specific primers was used for HBV DNA extraction and genotyping.

Main Results:

  • Genotype D was the only HBV genotype identified in both acute and chronic hepatitis patients.
  • Sequencing analysis confirmed 98%-99% homology with known HBV genotype D sequences.
  • No significant association was found between HBV genotype D and different infection types.

Conclusions:

  • HBV genotype D is the predominant genotype in Eastern Azerbaijan Province, Iran.
  • The findings contribute to the understanding of HBV epidemiology in Northwest Iran.
  • Further research may explore genotype-specific treatment responses.
Abstract

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