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Plasma active and inactive renin concentrations in children
1Department of Pediatrics, Yamanashi Medical College, Japan.
Hormone Research
|January 1, 1990
Summary
Plasma active renin concentration (PARC) and inactive renin concentration (PIRC) levels change with age and body position. Infants have higher PARC and PIRC, while standing increases both, suggesting developmental and positional effects on renin activity.
Area of Science:
- Endocrinology
- Pediatric Physiology
- Renal Physiology
Background:
- Renin, a key enzyme in the renin-angiotensin-aldosterone system, exists in active and inactive forms.
- Understanding age-related and positional changes in plasma active and inactive renin concentrations (PARC and PIRC) is crucial for pediatric and endocrine research.
Purpose of the Study:
- To investigate age-related variations in PARC and PIRC in children from 1 month to 15 years.
- To examine the impact of a short-term upright posture on PARC and PIRC.
- To explore the influence of puberty and the menstrual cycle on renin concentrations.
Main Methods:
- Plasma active and inactive renin concentrations (PARC and PIRC) were quantified using immunoradiometric assays.
- Study included 78 normal children aged 1 month to 15 years.
- Seven postmenarcheal girls were assessed in both supine and upright positions (15 minutes).
Main Results:
- Infants exhibited significantly higher PARC and PIRC compared to older children, with a lower PARC/PIRC ratio.
- During puberty, premenarcheal girls showed higher PARC, PIRC, and their ratio than postmenarcheal girls.
- A 15-minute upright position led to significant increases in PARC, PIRC, and the PARC/PIRC ratio.
Conclusions:
- Infants may have increased inactive renin production with potentially lower renin activation.
- Renin activation appears to be influenced by the menstrual cycle in adolescent girls.
- Short-term standing stimulates both the production and activation of renin.