Related Experiment Video

Updated: May 21, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Differences between developed and developing countries in paediatric care in haemophilia

P De Kleijn1, T Odent, E Berntorp

  • 1UMC, Utrecht, The Netherlands. pkleijn@umcutrecht.nl

Haemophilia : the Official Journal of the World Federation of Hemophilia
|June 26, 2012
PubMed

Insights

This article reviews global paediatric haemophilia care, focusing on medical, rehabilitation, and surgical treatments. It highlights the critical role of these interventions due to frequent musculoskeletal bleeding in people with haemophilia (PWH).

Area of Science:

  • Paediatric Haematology
  • Orthopaedic Surgery
  • Rehabilitation Medicine

Background:

  • Haemophilia is a genetic bleeding disorder primarily affecting joints and the musculoskeletal system.
  • Over 90% of bleeding episodes in people with haemophilia (PWH) impact the musculoskeletal system.
  • Joint bleeds constitute approximately 80% of all bleeding events in PWH.

Purpose of the Study:

  • To present a comprehensive, current overview of paediatric haemophilia care worldwide.
  • To emphasize the integrated roles of medical treatment, rehabilitation, and orthopaedic surgery.
  • To underscore the significance of musculoskeletal health management in PWH.

Main Methods:

  • Literature review of recent advancements in haemophilia management.
  • Synthesis of guidelines and best practices in paediatric haemophilia care.
  • Analysis of the impact of medical, rehabilitative, and surgical interventions.

Main Results:

  • Current paediatric haemophilia care involves a multidisciplinary approach.
  • Early and consistent medical treatment, physiotherapy, and surgical interventions are crucial.
  • Effective management strategies significantly improve outcomes and quality of life for PWH.

Conclusions:

  • Optimized paediatric haemophilia care requires coordinated efforts across medical, rehabilitation, and surgical specialties.
  • Addressing musculoskeletal complications is paramount for long-term health in PWH.
  • Continuous updates in treatment protocols are essential for global haemophilia management.

More Related Videos

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...