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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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NF-κB as a target for modulating inflammatory responses.

Chiara Gasparini1, Marc Feldmann

  • 1Institute for Maternal and Child Health IRCCS “Burlo Garofolo”, Trieste, Italy.

Current Pharmaceutical Design
|June 26, 2012
PubMed
Summary
This summary is machine-generated.

Nuclear Factor -κB (NF-κB) is crucial for inflammation and host defense, regulating genes in both pro-inflammatory and anti-inflammatory phases. Targeting NF-κB pathways offers therapeutic potential for various diseases.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Inflammation is central to host defense and disease pathology.
  • Nuclear Factor -κB (NF-κB) is a key transcription factor regulating inflammatory gene expression.
  • NF-κB is involved in both the initiation and resolution of inflammation.

Purpose of the Study:

  • To review the role and regulation of NF-κB in inflammation.
  • To explore therapeutic targeting strategies for NF-κB signaling pathways.
  • To consider the potential of NF-κB targeted dendritic cells in immunotherapy.

Main Methods:

  • Review of existing literature on NF-κB.
  • Description of NF-κB canonical and non-canonical pathways.
  • Analysis of kinases, interactions, and cellular responses involved in NF-κB activation.

Main Results:

  • NF-κB orchestrates inflammatory and anti-inflammatory responses.
  • Two main pathways (canonical and non-canonical) of NF-κB activation are detailed.
  • Various molecular targets within NF-κB pathways (IKKs, IκBα, NF-κB subunits) are identified for therapeutic intervention.

Conclusions:

  • NF-κB signaling is a critical regulator of inflammation with dual roles.
  • Targeting NF-κB offers a promising strategy for treating inflammatory diseases.
  • NF-κB targeted dendritic cells represent a potential avenue for immunotherapy.