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Related Experiment Video

Updated: May 21, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Visceral heterotaxy in the developing world.

Deepak Kishinchand Changlani¹, Monika Kotecha, Trupti Dongre Changlani

¹Department of Pediatric Cardiology, Institute of Cardio-Vascular Diseases, The Madras Medical Mission, Mogappair, Chennai, India.

Heart, Lung & Circulation

|June 26, 2012

Summary

This summary is machine-generated.

Visceral heterotaxy (VH) presents unique challenges in developing nations, often diagnosed late and with many inoperable cases. Left isomerism (LI) shows better surgical outcomes and survival compared to right isomerism (RI).

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Area of Science:

Pediatric Cardiology
Congenital Heart Disease
Medical Imaging

Background:

Visceral heterotaxy (VH) is a complex congenital condition with limited analysis in developing regions.
Understanding VH presentation and outcomes in resource-limited settings is crucial.

Purpose of the Study:

To analyze the clinical profile and surgical outcomes of visceral heterotaxy (VH) in a developing country.
To compare outcomes between right isomerism (RI) and left isomerism (LI) subtypes.

Main Methods:

Retrospective chart review of 69 VH patients over ten years.
Diagnosis via echocardiography, blood smear, Multi-Detector Computed Tomography (MDCT) angiogram, and surgical inspection.

Main Results:

Left isomerism (LI) had a lower surgical mortality (3.8%) than right isomerism (RI) (5%).
Long-term survival was higher for LI patients; un-operated patients had higher mortality (33%).
Late mortality causes included sepsis, heart failure, and arrhythmia.

Conclusions:

Visceral heterotaxy (VH) is diagnosable using imaging criteria.
VH presents late in developing countries, with a high proportion of inoperable cases.
Left isomerism (LI) demonstrates superior surgical results and long-term survival compared to right isomerism (RI).