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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

[Extramedullary plasmocytomas].

H Ben Salah1, S Hdiji, S Makni

  • 1Service de radiothérapie carcinologique, CHU Habib-Bourguiba, Sfax, Tunisie. ben_salah_hanen@yahoo.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|June 26, 2012
PubMed
Summary
This summary is machine-generated.

Extramedullary plasmocytoma is a rare condition that can appear anywhere in the body, most commonly in the head and neck. Treatment, often radiotherapy, leads to high remission rates, but progression to myeloma impacts prognosis.

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Area of Science:

  • Oncology
  • Pathology

Context:

  • Extramedullary plasmocytoma (EMP) is a rare plasma cell neoplasm.
  • Diagnosis relies on histopathology, immunohistochemistry, and exclusion of multiple myeloma.

Purpose:

  • To investigate the characteristics, management, and outcomes of extramedullary plasmocytoma.
  • To analyze a series of eight patients and review existing literature.

Summary:

  • Eight patients with EMP were treated, with common sites including the nasal cavity, lymph nodes, and reproductive organs.
  • Radiotherapy and chemotherapy were primary treatment modalities, achieving an 86% complete remission rate.
  • While most patients achieved remission, nodal recurrence occurred in two cases; progression to multiple myeloma is a key prognostic factor.

Impact:

  • This study highlights the diverse presentations and effective treatment strategies for EMP.
  • Understanding prognostic factors like myeloma progression is crucial for patient management and improving outcomes.