Related Experiment Video
Updated: May 21, 2026

09:42
Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons
Published on: August 17, 2012
DLK: the "preconditioning" signal for axon regeneration?
1Biology Department, University of Utah, Salt Lake City, UT 84112, USA.
Neuron
|June 26, 2012
Abstract:
In this issue of Neuron, Shin et al. (2012) show that the dual leucine zipper kinase (DLK) is responsible for the retrograde injury signal in spinal sensory and motor neurons. DLK is required for the accelerated regeneration seen after axotomy and for the improved regeneration seen after a conditioning injury. DLK KO axons have severely reduced axon regeneration in vivo.
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