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Related Experiment Videos

Amiodarone--efficacy and late potentials during long-term therapy.

L Goedel-Meinen1, M Hofmann, G Schmidt

  • 1Technical University of Munich, Germany.

International Journal of Clinical Pharmacology, Therapy, and Toxicology
|November 1, 1990
PubMed
Summary

Long-term amiodarone therapy significantly increased QRS duration in patients with heart disease and ventricular arrhythmias. Signal-averaged ECG and Holter monitoring showed no direct correlation in this study.

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Amiodarone is a potent antiarrhythmic drug used for ventricular arrhythmias.
  • Signal-averaged ECG (SAECG) and Holter monitoring are key diagnostic tools in arrhythmia assessment.
  • Assessing the impact of amiodarone on SAECG parameters and its correlation with Holter data is clinically relevant.

Purpose of the Study:

  • To investigate the long-term effects of amiodarone on signal-averaged ECG parameters.
  • To evaluate the relationship between signal-averaged ECG findings and Holter monitoring data during amiodarone therapy.
  • To assess amiodarone's efficacy in patients with refractory ventricular arrhythmias.

Main Methods:

  • Prospective study design involving 27 patients with dilated cardiomyopathy or coronary heart disease and high-grade ventricular arrhythmias.

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  • Patients were treated with amiodarone after failure of multiple Class I antiarrhythmic drugs.
  • Serial ECG, signal-averaged ECG, and 24-hour Holter monitoring were performed before and during amiodarone therapy.

    • Main Results:

    • A significant increase in the total filtered QRS complex duration was observed with amiodarone treatment.
    • The incidence of late potentials on signal-averaged ECG remained stable.
    • Holter monitoring indicated a responder rate of 46-81% to amiodarone therapy.
    • No significant correlation was found between signal-averaged ECG parameters and Holter monitoring results.

    Conclusions:

    • Long-term amiodarone therapy leads to significant changes in QRS duration on signal-averaged ECG.
    • Amiodarone demonstrates a substantial responder rate for ventricular arrhythmias as assessed by Holter monitoring.
    • Signal-averaged ECG and Holter monitoring provide complementary, but not directly correlated, information in patients on amiodarone.