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Interaction between nifedipine and cardioactive drugs.
K O Haustein1, I Assmann, G Hüller
1Institute of Clinical Pharmacology, Medical Academy Erfurt, Germany.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|November 1, 1990
Summary
This study investigated nifedipine (N) and dehydronifedipine (DHN) plasma levels in cardiovascular patients. Long-term treatment with cardioactive drugs did not inhibit nifedipine degradation.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Nifedipine is a common cardiovascular drug.
- Understanding its metabolism in patients with cardiovascular diseases is crucial.
Purpose of the Study:
- To measure plasma levels of nifedipine (N) and dehydronifedipine (DHN) in patients with cardiovascular diseases.
- To assess the impact of long-term co-administration of cardioactive drugs on N metabolism.
Main Methods:
- Gas chromatography was used to quantify N and DHN plasma levels.
- Measurements were taken in 37 patients before and after a 20 mg N dose.
- Blood pressure and heart rate were monitored concurrently.
Main Results:
- In healthy volunteers, mean plasma N was 47.7 ng/mL and DHN was 46.7 ng/mL 2 hours post-dose.
- In patients, mean plasma N increased from 14.1 to 34.1 ng/mL, and DHN from 5.4 to 16.0 ng/mL.
- The DHN/N ratio was lower in patients (0.59) than in volunteers (0.83), suggesting altered metabolism, but no inhibition was observed.
Conclusions:
- Long-term treatment with cardioactive drugs did not inhibit nifedipine degradation in patients with cardiovascular diseases.
- The observed differences in DHN/N ratios indicate potential alterations in nifedipine metabolism in this patient group.