Related Experiment Video
Updated: May 21, 2026
07:25
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Primary synovial sarcoma involving the submandibular gland
Fernanda Viviane Mariano1, Rogério Oliveira Gondak, Matheus Vieira da Costa
1Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. nanda@fop.unicamp.br
Summary
This case report details a rare monophasic synovial sarcoma in an 18-year-old male
Area of Science:
- Head and Neck Oncology
- Soft Tissue Pathology
- Surgical Oncology
Background:
- Synovial sarcoma is a malignant soft tissue tumor, typically affecting young adults in the extremities.
- Head and neck region involvement is rare (10%), with biphasic subtypes being more common.
- Submandibular gland involvement by synovial sarcoma is exceptionally uncommon.
Observation:
- An 18-year-old male presented with a 12-month history of a right submandibular mass.
- Surgical excision revealed a tumor composed of malignant spindle cells within the submandibular gland.
- Immunohistochemistry confirmed positivity for markers including AE1/AE3, CK18/8, EMA, CD99, CD56, and TLE-1.
Findings:
- Histopathological and immunohistochemical analysis led to the diagnosis of monophasic synovial sarcoma.
- This represents the first documented instance of synovial sarcoma originating in the submandibular gland.
- The patient achieved disease-free status after 1 year following adjuvant radiotherapy.
Implications:
- Highlights the importance of considering rare diagnoses in head and neck masses.
- Contributes to the understanding of synovial sarcoma's diverse anatomical distribution.
- Emphasizes the potential for successful treatment outcomes with multimodal therapy in rare sarcoma presentations.
