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Subungual leukemia cutis.

C A Simon1, W P Su, C Y Li

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

International Journal of Dermatology
|November 1, 1990
PubMed
Summary
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This study reports the first case of chronic lymphocytic leukemia (CLL) presenting as subungual tumors. Nail abnormalities and tumors led to the CLL diagnosis, highlighting a rare clinical manifestation.

Area of Science:

  • Oncology
  • Dermatology
  • Hematology

Background:

  • Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy.
  • Subungual tumors typically have diverse etiologies.
  • Nail abnormalities can sometimes indicate systemic disease.

Observation:

  • A 79-year-old male presented with generalized nail pitting and subungual tumors on fingers and the left big toe.
  • Histologic examination of the subungual tumors was performed.
  • Peripheral blood smear analysis was conducted.

Findings:

  • Histopathology and peripheral blood smear findings confirmed the diagnosis of chronic lymphocytic leukemia (CLL).
  • The subungual tumors were identified as a manifestation of CLL.
  • This represents the first documented case of CLL involving the subungual region.

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Implications:

  • The case highlights an unusual presentation of CLL.
  • Subungual tumors warrant thorough investigation, including biopsy, for accurate diagnosis.
  • This finding expands the differential diagnosis for subungual tumors.