Proteasome and neurodegeneratıve diseases
1Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, Haydarpasa, Istanbul, Turkey.
Abstract:
Proteasomal degradation of damaged proteins is involved in the pathogenesis of many neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, stroke, and amyotrophic lateral sclerosis. A malfunction of the proteasomal activity may be the result or the consequence of protein aggregation, which is a key process for most neurodegenerative diseases. Because of the widespread aspects of the proteasomal involvement in the progression of these diseases, many studies are focused on this research.
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