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Updated: May 21, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
Published on: August 27, 2021
Mirror image phage display--generating stable therapeutically and diagnostically active peptides with
Na Sun1, Susanne Aileen Funke, Dieter Willbold
1ICS-6, Forschungszentrum Jülich, 52425 Jülich, Germany.
Abstract:
Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches.
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