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Related Experiment Video

Updated: May 21, 2026

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter
08:29

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

Published on: April 22, 2014

High throughput miniature drug-screening platform using bioprinting technology.

Jorge I Rodríguez-Dévora1, Bimeng Zhang, Daniel Reyna

  • 1Department of Mechanical Engineering and Biomedical Engineering Program, University of Texas at El Paso, El Paso, TX 79968, USA.

Biofabrication
|June 26, 2012
PubMed
Summary
This summary is machine-generated.

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A novel inkjet drug-screening platform offers a cost-effective, high-speed method for evaluating biochemical reactions. This technology significantly reduces drug development time and investment, improving target evaluation in pharmaceutical research.

Area of Science:

  • Pharmaceutical Science
  • Biotechnology
  • Microfluidics

Background:

  • Drug development is costly and time-consuming.
  • Current target evaluation processes have limited throughput.
  • Novel compounds are expensive, increasing development costs.

Purpose of the Study:

  • To develop a novel inkjet-based deposition method for drug screening.
  • To create a miniature drug-screening platform for high-speed, low-volume biochemical reaction evaluation.
  • To reduce the cost and time associated with drug discovery.

Main Methods:

  • Utilized a modified Hewlett Packard compact disc printer for inkjet-based deposition.
  • Arrayed green fluorescent protein expressing Escherichia coli cells in alginate gel on a coverslip chip.

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High-Throughput Bioprinting Method for Modeling Vascular Permeability in Standard Six-well Plates with Size and Pattern Flexibility
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High-Throughput Bioprinting Method for Modeling Vascular Permeability in Standard Six-well Plates with Size and Pattern Flexibility

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Last Updated: May 21, 2026

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter
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The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

Published on: April 22, 2014

High-Throughput Bioprinting Method for Modeling Vascular Permeability in Standard Six-well Plates with Size and Pattern Flexibility
07:41

High-Throughput Bioprinting Method for Modeling Vascular Permeability in Standard Six-well Plates with Size and Pattern Flexibility

Published on: August 16, 2024

  • Patterned antibiotic droplets to evaluate bacterial inhibition for antibiotic screening.

    • Main Results:

    • Achieved repeatable droplet volumes of 180% ± 26% picoliters.
    • Demonstrated high cell viability (>98%) and minimal DNA damage to human kidney cells.
    • Validated the platform's effectiveness compared to current screening processes.

    Conclusions:

    • The inkjet-based platform offers a realistic and inexpensive method for high-speed, picoliter-scale drug screening.
    • This technique has the potential to significantly improve the drug discovery process.
    • Reduced investment and compound volume usage enhance efficiency in target evaluation.