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Updated: May 21, 2026
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese
Chao Liu1, Guansan Wang, Hong Liu
1Guangzhou Forensic Science Institution, Guangdong Provincial Key Laboratory of Forensic Genetic, China.
Background:
Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.
Objectives:
The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.
Methods:
Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.
Results:
The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.
Conclusions:
CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.
