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Related Experiment Video

Updated: May 21, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Current concepts in glucocorticoid resistance.

Nan Yang1, David W Ray, Laura C Matthews

  • 1Endocrine Sciences Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

Steroids
|June 26, 2012
PubMed
Summary
This summary is machine-generated.

Glucocorticoids (GCs) are potent anti-inflammatories, but variable patient response limits use. Understanding acquired GC resistance mechanisms can enable safer, low-dose therapies for inflammatory diseases.

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Last Updated: May 21, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

Area of Science:

  • Pharmacology
  • Immunology
  • Molecular Biology

Background:

  • Glucocorticoids (GCs) are powerful anti-inflammatory drugs.
  • Varied patient response to GCs, particularly in chronic inflammatory diseases, necessitates higher doses and increases side effect risks.
  • Acquired GC resistance, distinct from rare genetic forms, is a significant clinical challenge.

Purpose of the Study:

  • To review the underlying mechanisms of acquired glucocorticoid resistance.
  • To explore factors contributing to localized GC resistance in chronic inflammation.
  • To discuss potential strategies for enhancing tissue GC sensitivity.

Main Methods:

  • Review of existing literature on glucocorticoid receptor (GR) function and resistance.
  • Analysis of cellular microenvironment factors implicated in acquired GC resistance.
  • Discussion of signaling pathways affected by chronic inflammation.

Main Results:

  • Acquired GC resistance is linked to chronic inflammation-induced changes in the cellular microenvironment.
  • Identified factors include altered GR-dependent and -independent signaling, oxidative stress, hypoxia, and serum factors.
  • Mechanisms underlying GC resistance are increasingly understood.

Conclusions:

  • Acquired GC resistance is a complex phenomenon driven by the inflammatory microenvironment.
  • Elucidating these mechanisms is crucial for improving GC therapy.
  • Enhancing tissue GC sensitivity could allow for safe, low-dose GC treatment in inflammatory conditions.