Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generalizable, high-throughput image analysis of subcellular structures using dispersion indices.

iScience·2026
Same author

Scalable workflows for high-throughput respirometry.

Life science alliance·2026
Same author

The liver regulates ectopic calcification in Abcc6-deficient models of pseudoxanthoma elasticum.

The Journal of clinical investigation·2026
Same author

Disrupted energy metabolism is associated with retinal ganglion cell degeneration in autosomal dominant optic atrophy.

Science advances·2026
Same author

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

Journal of cachexia, sarcopenia and muscle·2025
Same author

STX4 is indispensable for mitochondrial homeostasis in skeletal muscle.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 21, 2026

Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

Mitochondrial dynamics: the intersection of form and function.

Andrew Ferree1, Orian Shirihai

  • 1Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA.

Advances in Experimental Medicine and Biology
|June 26, 2012
PubMed
Summary

Mitochondrial dynamics, the balance of fusion and fission, shape cellular adaptability. Disruptions in mitochondrial dynamics are implicated in Parkinson

Area of Science:

  • Cell Biology
  • Neuroscience
  • Mitochondrial Biology

Background:

  • Mitochondria exist as a dynamic population, constantly undergoing fusion and fission.
  • This morphological plasticity allows cells to adapt to metabolic demands and stress.
  • Mitochondrial dynamics are crucial for normal cellular function.

Purpose of the Study:

  • To introduce the emerging field of mitochondrial dynamics.
  • To explore the role of mitochondrial dynamics in cellular adaptation.
  • To investigate the link between mitochondrial dynamics dysfunction and Parkinson's disease.

Main Methods:

  • Review of current literature on mitochondrial dynamics.
  • Analysis of cellular mechanisms regulating mitochondrial fusion and fission.

More Related Videos

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
08:15

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

Published on: August 15, 2025

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells
06:14

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells

Published on: November 14, 2025

Related Experiment Videos

Last Updated: May 21, 2026

Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
08:15

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

Published on: August 15, 2025

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells
06:14

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells

Published on: November 14, 2025

  • Examination of neuronal characteristics in Parkinson's disease.

    • Main Results:

    • Mitochondrial shape is determined by the balance of fusion and fission processes.
    • Mitochondrial dynamics provide adaptive flexibility for cellular stress.
    • Dysfunction in mitochondrial dynamics is a potential mechanism in Parkinson's disease.

    Conclusions:

    • Mitochondrial dynamics is a critical area of cell biology with implications for disease.
    • Understanding these dynamics is key to comprehending cellular health.
    • Specific neuronal vulnerabilities in Parkinson's disease may stem from disrupted mitochondrial dynamics.