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Updated: May 21, 2026
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Synthesis, Assembly, and Characterization of Monolayer Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry
Published on: October 4, 2011
The interplay of monolayer structure and serum protein interactions on the cellular uptake of gold nanoparticles
Zheng-Jiang Zhu1, Tamara Posati, Daniel F Moyano
1Department of Chemistry, University of Massachusetts, Amherst, 01003 USA.
Small (Weinheim an Der Bergstrasse, Germany)
|June 26, 2012
Abstract:
A critical factor for controlling serum albumin binding is surface hydrophobicity, which in turn decreases the cellular uptake of gold nanoparticles. Hydrophobic nanoparticles bind albumin more tightly, inhibiting particle uptake, with a direct correlation observed between uptake and surface hydrophobicity.
