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Updated: May 21, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Published on: November 5, 2016
Antimicrobial hydantoin-containing polyesters
Licheng Tan1, Samarendra Maji, Claudia Mattheis
1Department of Chemistry and WZMW, Philipps-Universität Marburg, Hans-Meerwein-Str., 35032 Marburg, Germany.
Abstract:
A new N-hydantoin-containing biocompatible and enzymatically degradable polyester with antibacterial properties is presented. Different polyesters of dimethyl succinate, 1,4-butanediol, and 3-[N,N-di(β-hydroxyethyl)aminoethyl]-5,5-dimethylhydantoin in varying molar ratios are prepared via two-step melt polycondensation. The antibacterially active N-halamine form is obtained by subsequent chlorination of the polyesters with sodium hypochlorite. Chemical structures, thermal properties, and spherulitic morphologies of the copolymers are studied adopting FT-IR, NMR, TGA, DSC, WAXD, and POM. The polyesters exhibit antibacterial activity against Escherichia coli. The adopted synthetic approach can be transferred to other polyesters in a straightforward manner.
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