Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Clinicogenomic Risk Modeling for Metachronous Second Primary Cancers.

medRxiv : the preprint server for health sciences·2026
Same author

Prevalence of Germline Pathogenic <i>RET</i> Variants in a Pan-Cancer Patient Population.

JCO precision oncology·2026
Same author

The impact of breast cancer polygenic risk score disclosure on decisional conflict around risk-reducing mastectomy in women with pathogenic BRCA1/2 variants.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer.

Nature·2026
Same author

"Where do I go from here?" Navigating a lifelong road without a map: the care experiences of hereditary cancer patients.

European journal of human genetics : EJHG·2026
Same author

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Related Experiment Video

Updated: May 21, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Genetic testing in gastrointestinal cancers: a case-based approach.

Kasmintan Schrader1, Kenneth Offit, Zsofia K Stadler

  • 1Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Oncology (Williston Park, N.Y.)
|June 27, 2012
PubMed
Summary

Identifying hereditary genetic mutations is crucial for gastrointestinal (GI) cancer prevention. Early detection in families enables proactive management and life-saving screenings or surgeries for at-risk individuals.

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Related Experiment Videos

Last Updated: May 21, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

  • Genetics and Oncology
  • Gastroenterology

Background:

  • Hereditary genetic mutations contribute to a small but significant portion of gastrointestinal (GI) cancer cases.
  • Early identification of individuals with genetic predispositions is vital for effective primary cancer prevention strategies.

Observation:

  • While only 5% of the population burden of GI cancers is linked to high-risk genetic mutations, these mutations have profound implications.
  • Families harboring genetic susceptibilities to GI cancers require targeted identification and management.

Findings:

  • Focus on hereditary aspects of common GI cancers: pancreatic, gastric, and colon cancer.
  • Case-based approach highlights the importance of genetic counseling and testing.

Implications:

  • Genetic susceptibility testing offers significant benefits for individual patient management.
  • Early identification of at-risk family members allows for enhanced cancer screenings and prophylactic surgeries.
  • Proactive interventions based on genetic risk can lead to dramatic life-prolonging benefits.