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An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
Developing a benchmarking process in perfusion: a report of the Perfusion Downunder Collaboration
Robert A Baker1, Richard F Newland, Carmel Fenton
1Cardiac and Thoracic Surgical Unit, Department of Medicine, Flinders Medical Centre and Flinders University of South Australia, Adelaide, South Australia, Australia. Rob.Baker@flinders.edu.au
This study aimed to improve perfusion practice by developing quality indicators for cardiopulmonary bypass procedures. The researchers collected data from eight centers in Australia and New Zealand using the Perfusion Downunder Collaboration database. They focused on three key parameters: blood glucose levels, arterial outlet temperature, and pCO2. Quality indicators were defined for each parameter, and benchmarks were calculated using the Achievable Benchmark of Care (ABC) methodology. The study found significant variation in performance across centers, with the best-performing centers providing a reference for improvement. The results suggest that these indicators can be used to guide quality improvements in perfusion practice.
Area of Science:
- Cardiovascular perfusion standards
- Clinical quality benchmarking in surgery
- Healthcare performance metrics
Background:
Establishing measurable standards for clinical performance is a critical step in healthcare improvement. Prior research has shown that benchmarking can help identify best practices and guide quality improvements. However, the field of perfusion lacks widely accepted quantitative indicators for cardiopulmonary bypass management. This gap motivated the Perfusion Downunder Collaboration to develop a multi-center database for perfusion data collection. Their goal was to define quality indicators that could be used to assess and improve clinical outcomes. The collaboration aimed to address the lack of standardized metrics in perfusion practice. By collecting data from multiple centers, they sought to identify patterns and performance benchmarks. This approach was intended to provide a framework for evaluating clinical performance. The effort was driven by the need to support evidence-based improvements in perfusion practice.
Purpose Of The Study:
The purpose of this study was to develop a benchmarking process for perfusion practice. The researchers aimed to define quality indicators for key parameters during cardiopulmonary bypass. These indicators would serve as a basis for evaluating clinical performance across multiple centers. The study focused on glucose levels, arterial outlet temperature, and pCO2 management. These parameters were selected based on their clinical relevance and potential for standardization. The goal was to derive benchmarks that could guide performance improvements. The collaboration aimed to use the Achievable Benchmark of Care (ABC) methodology to identify best practices. This approach was intended to provide a platform for quality improvement in perfusion.
Main Methods:
The study used a multi-center database called the Perfusion Downunder Collaboration database. Data were collected from eight cardiac centers in Australia and New Zealand between March 2007 and February 2011. The database captured information on cardiopulmonary bypass procedures. The researchers selected three key parameters for quality indicators: glucose levels, arterial outlet temperature, and pCO2. They defined specific ranges for each indicator based on clinical consensus. The Achievable Benchmark of Care (ABC) methodology was used to analyze performance data. The ABC approach identified the best-performing centers to derive benchmarks. A total of 5,465 procedures were evaluated to calculate quality indicators and benchmarks.
Main Results:
The study found that blood glucose levels met the quality indicator in 37-96% of procedures, with a benchmark of 90%. Arterial outlet temperature met the indicator in 16-98% of cases, with a benchmark of 94%. Arterial pCO2 levels met the indicator in 21-91% of procedures, with a benchmark of 80%. These benchmarks were derived from the best-performing centers in the database. The data showed significant variation in performance across centers. The highest-performing centers demonstrated the most consistent adherence to the indicators. The benchmarks provide a reference for evaluating clinical performance. The results suggest that these indicators can be used to guide quality improvements in perfusion.
Conclusions:
The study concludes that quality indicators and benchmarks can be derived for key aspects of cardiopulmonary bypass management. The researchers propose that these indicators provide a platform for improving perfusion practice. The benchmarks reflect the best performance observed across multiple centers. The findings suggest that standardized metrics can support clinical improvement efforts. The authors state that these indicators can be used to evaluate and guide perfusion practice. The study does not claim that these indicators are essential for all clinical settings. The results may suggest that benchmarking can help identify best practices. The authors propose that these findings can inform future quality improvement initiatives.
Frequently Asked Questions
The study defines quality indicators for blood glucose levels (4–10 mmol/L), arterial outlet temperature (≤37°C), and pCO2 (35–45 mmHg) during cardiopulmonary bypass.
Benchmarks were calculated using the Achievable Benchmark of Care (ABC) methodology, which identifies performance levels from the best-performing centers in the database.
The database was used to collect data from eight centers in Australia and New Zealand, enabling the researchers to derive standardized quality indicators for perfusion practice.
The ABC methodology helps identify best practices by analyzing performance data from the highest-performing centers to set achievable benchmarks.
A total of 5,465 procedures were evaluated to derive quality indicators and benchmarks for perfusion practice.
The study suggests that standardized quality indicators and benchmarks can serve as a platform for improving perfusion practice across multiple centers.

