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Cutaneous angiolipoleiomyoma
J E Fitzpatrick1, J R Mellette, R J Hwang
1Department of Medicine, Fitzsimons Army Medical Center, Aurora, CO 80045.
Journal of the American Academy of Dermatology
|December 1, 1990
Summary
This study details eight cases of cutaneous angiolipoleiomyoma, a rare skin tumor. These acquired, solitary nodules occurred on the extremities in adults, distinct from tuberous sclerosis-associated tumors.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Cutaneous angiolipoleiomyoma is an exceptionally rare tumor, with only one prior report documented as cutaneous angiomyolipoma.
- Understanding the clinical and histological spectrum of rare cutaneous neoplasms is crucial for accurate diagnosis and patient management.
Purpose of the Study:
- To present a series of eight cases of cutaneous angiolipoleiomyoma.
- To characterize the clinical presentation, histological features, and demographic data of this rare tumor.
Main Methods:
- Case series review of eight patients diagnosed with cutaneous angiolipoleiomyoma.
- Clinical data collection including patient age, sex, and tumor location.
- Histopathological examination of tumor morphology, including smooth muscle, vascular components, connective tissue, and adipose tissue.
Main Results:
- Eight acquired, solitary, asymptomatic acral nodules were identified.
- Patients ranged from 33 to 77 years (median 52.6 years) with a 7:1 male/female ratio.
- Histology revealed subcutaneous tumors with variable proportions of smooth muscle and mature fat, alongside vascular spaces and connective tissue; some vessels lacked elastic laminae.
Conclusions:
- Cutaneous angiolipoleiomyoma presents as a distinct entity, typically as an acquired, solitary, acral nodule in adults.
- The histological composition is variable, featuring smooth muscle, vascular elements, and mature fat.
- Absence of tuberous sclerosis or renal angiomyolipoma signs suggests a non-syndromic etiology for these cutaneous tumors.