Related Experiment Video
Updated: Aug 16, 2026

Milk Collection in the Rat Using Capillary Tubes and Estimation of Milk Fat Content by Creamatocrit
Published on: December 16, 2015
Metabolism of vitamin K and influence on prothrombin time in milk-fed preruminant calves
1Department of Dairy Science, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691.
Abstract:
The metabolism of vitamin K was studied in 66 preruminant veal calves that were fed supplemental menadione sodium bisulfite complex or phylloquinone. Menadione sodium bisulfite complex was converted by intestinal microorganisms to menaquinone-4 and absorbed and stored in the liver as menaquinone-4. Phylloquinone was absorbed unchanged. Production of menaquinones 6, 7, 8, and 10 by intestinal microorganisms also was observed, but was not dependent upon dietary vitamin K. No difference was noted in prothrombin time among the groups. Intestinal microorganisms provide sufficient vitamin K to meet the physiological needs of calves fed milk replacers. Menaquinone-4 was the form of vitamin K used to meet the calf's requirement.
Related Concept Videos
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Determination of Michaelis Constant and Maximum Elimination Rate
These parameters can be estimated by analyzing plasma concentration data post-drug administration. A notable example of this application is phenytoin, a drug with capacity-limited kinetics. It's recommended that phenytoin should be administered at two...
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

