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In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

SUMOylation of claudin-2

Christina M Van Itallie1, Laura L Mitic, James M Anderson

  • 1National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Christina.VanItallie@nih.gov

Annals of the New York Academy of Sciences
|June 27, 2012
PubMed
Summary

Claudin-2 protein levels are regulated by SUMOylation, a cellular modification. This study identifies a specific SUMOylation site on claudin-2, suggesting a novel mechanism for controlling its cellular abundance and membrane expression.

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