Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Neurotransmitters01:31

Neurotransmitters

Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents01:20

Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zcf24, a zinc-finger transcription factor, is required for lactate catabolism and inhibits commensalism in Candida albicans.

Molecular microbiology·2022
Same author

Human reliability assessment of intelligent coal mine hoist system based on Bayesian network.

Scientific reports·2022
Same author

Application of Deep Learning on Single-cell RNA Sequencing Data Analysis: A Review.

Genomics, proteomics & bioinformatics·2022
Same author

Distinct clinical pattern of colorectal cancer patients with POLE mutations: A retrospective study on real-world data.

Frontiers in genetics·2022
Same author

Natural oscillation frequencies of a Rayleigh sphere levitated in standing acoustic waves.

The Journal of the Acoustical Society of America·2022
Same author

Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.

Journal of medicinal chemistry·2022
Same journal

Oxytocin receptor or vasopressin 1a receptor knockout suppresses same-sex conspecific aggression without affecting partner preference in male prairie voles (Microtus ochrogaster).

Hormones and behavior·2026
Same journal

Timed melatonin administration increases territorial but not non-territorial aggression in female Siberian hamsters.

Hormones and behavior·2026
Same journal

Neuroendocrine signatures of urban aggression: Arginine vasotocin (AVT) receptor distribution and expression in male song sparrow (Melospzia melodia) brain.

Hormones and behavior·2026
Same journal

Hormones, sex differences, and autism: From single-cause theories to integrated developmental systems.

Hormones and behavior·2026
Same journal

Androgen receptor activation is involved in maintaining goal-directed behavior in levonorgestrel-treated female rats.

Hormones and behavior·2026
Same journal

Sleep hygiene behaviors and actigraphic sleep: a pilot analysis of gender differences.

Hormones and behavior·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Progesterone and neuroprotection.

Meharvan Singh1, Chang Su

  • 1Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA. meharvan.singh@unthsc.edu

Hormones and Behavior
|June 27, 2012
PubMed
Summary
This summary is machine-generated.

Progesterone, not just estrogen, plays a crucial role in brain health and may offer neuroprotection. Understanding progesterone

More Related Videos

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Experimental Methods for Testing the Effects of Neurotrophic Peptide, ADNF-9, Against Alcohol-induced Apoptosis during Pregnancy in C57BL/6 Mice
09:50

Experimental Methods for Testing the Effects of Neurotrophic Peptide, ADNF-9, Against Alcohol-induced Apoptosis during Pregnancy in C57BL/6 Mice

Published on: April 24, 2013

Related Experiment Videos

Last Updated: May 21, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Experimental Methods for Testing the Effects of Neurotrophic Peptide, ADNF-9, Against Alcohol-induced Apoptosis during Pregnancy in C57BL/6 Mice
09:50

Experimental Methods for Testing the Effects of Neurotrophic Peptide, ADNF-9, Against Alcohol-induced Apoptosis during Pregnancy in C57BL/6 Mice

Published on: April 24, 2013

Area of Science:

  • Neurobiology
  • Endocrinology
  • Neuroprotection

Background:

  • Ovariectomy models often overlook the loss of progesterone alongside estrogen.
  • Menopause-induced decline in both estrogen and progesterone may contribute to cognitive deficits and neurodegenerative disease risk.
  • Progesterone demonstrates neuroprotective effects across various models, including human studies.

Purpose of the Study:

  • To review evidence supporting progesterone's neuroprotective effects.
  • To discuss proposed mechanisms underlying progesterone's neuroprotection.
  • To explore progesterone receptor pharmacology and its role in neuroprotection.

Main Methods:

  • Review of existing scientific literature on progesterone and neuroprotection.
  • Analysis of cell, animal, and human studies investigating progesterone's effects on the brain.
  • Examination of receptor pharmacology and proposed mechanisms of action.

Main Results:

  • Evidence supports progesterone's significant role in neuroprotection.
  • Multiple mechanisms mediate progesterone's protective effects on neural cells.
  • Progesterone receptor subtypes and signaling pathways are key to its neurobiological actions.

Conclusions:

  • Progesterone's neuroprotective actions are multifaceted and significant.
  • The distinct neurobiology of progesterone versus synthetic progestins may explain differential clinical outcomes.
  • The type of progestin used is critical for brain health outcomes in clinical studies.