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Updated: May 21, 2026

A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
Oxygen in wound healing: nutrient, antibiotic, signaling molecule, and therapeutic agent
1Millburn Surgical Associates, 225 Millburn Avenue, Suite 104-B, Millburn, NJ 07041, USA. dave@njdave.net
Abstract:
Disturbances to healing observed under hypoxic conditions have given insights into the roles of oxygen. Wound hypoxia is more prevalent than generally appreciated, and occurs even in patients who are free of arterial occlusive disease. There is a strong scientific basis for oxygen treatment as prophylaxis against infection, to facilitate wound closure, and to prevent amputation in wounded patients. This article reviews extensive data from preclinical and human trials of supplemental inhaled oxygen, hyperbaric oxygen, and topical oxygen treatment. Oxygen supports biochemical metabolism and cellular function, and has roles in combating infection and facilitating the wound healing cascade.
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