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Renal functional reserve in children with apparently normal congenital solitary functioning kidney

Amira Peco-Antić1, Dušan Paripović, Jelena Kotur-Stevuljević

  • 1Medical Faculty, University of Belgrade, Belgrade, Serbia. amirapecoantic@yahoo.com

Clinical Biochemistry
|June 27, 2012
PubMed

Insights

In children with a single functioning kidney, half showed reduced renal functional reserve (RFR). Serum cystatin C levels effectively predict RFR in these patients.

Area of Science:

  • Pediatric Nephrology
  • Renal Physiology

Background:

  • Congenital solitary functioning kidney (SFK) can present with normal appearance but potential subclinical renal impairment.
  • Assessing renal functional reserve (RFR) is crucial for understanding kidney health in these children.

Purpose of the Study:

  • To investigate RFR in children with apparently normal SFK.
  • To determine the relationship between RFR, serum cystatin C, and blood pressure in this cohort.

Main Methods:

  • RFR was measured by the change in endogenous creatinine clearance (CrCs) after an oral protein load (OPL).
  • Serum cystatin C and urinary protein excretion were assessed before and after OPL.
  • Patients received cimetidine pre-treatment.

Main Results:

  • Over half (54.5%) of the 22 children studied had decreased RFR.
  • Elevated serum cystatin C was observed in 72.7% of patients.
  • Serum cystatin C was a strong predictor, explaining over 90% of RFR variability.

Conclusions:

  • A significant proportion of children with apparently normal SFK exhibit reduced RFR.
  • Serum cystatin C is a valuable biomarker for predicting RFR in pediatric SFK patients.
Abstract

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