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Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

Urinary Tract Calculi III: Medical Management

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

Disorders of the Urinary System

Disorders of the Urinary System

The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...

Physiology of the Genitourinary System III: Urine Concentration and Dilution

Physiology of the Genitourinary System III: Urine Concentration and Dilution

The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...

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Updated: May 21, 2026

Injection of Porcine Adipose Tissue-Derived Stroma Cells via Waterjet Technology

Injection of Porcine Adipose Tissue-Derived Stroma Cells via Waterjet Technology

Published on: November 23, 2021

[Cellular therapy and urinary incontinence].

R Boissier¹, G Karsenty

¹Service d'urologie et transplantation rénale, Aix-Marseille université, hôpital de la Conception, 147, boulevard Baille, 13005 Marseille, France. romainboissier@hotmail.com

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie

|June 27, 2012

Summary

This summary is machine-generated.

Stem cell therapy shows promising short-term results for treating stress urinary incontinence (SUI). Mesenchymal stem cells (MSCs) derived from various tissues may regenerate sphincter function, with clinical studies reporting variable success rates.

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Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

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Area of Science:

Regenerative Medicine
Urology
Cell Biology

Context:

Stress urinary incontinence (SUI) affects a significant portion of the population, impacting quality of life.
Current treatments for SUI have limitations and varying success rates.
Stem cell therapy presents a novel therapeutic avenue for SUI.

Purpose:

To review preclinical and clinical literature on stem cell therapy for stress urinary incontinence.
To evaluate the efficacy and safety of mesenchymal stem cells (MSCs) in treating SUI.
To synthesize findings from studies using bone marrow, striated muscle, and adipose tissue-derived MSCs.

Summary:

Mesenchymal stem cells (MSCs) from bone marrow, muscle, and adipose tissue have been investigated for SUI treatment.
Preclinical studies demonstrate MSCs can differentiate into contractile myocytes and restore nerve junctions.
Clinical studies show variable success rates (12-79% complete continence) and improvements (13-66%) with a median follow-up of 1 year.

Impact:

Stem cell therapy offers a potentially effective and minimally invasive option for SUI management.
Encouraging short-term outcomes and a favorable safety profile suggest further clinical investigation is warranted.
This review highlights the therapeutic potential of regenerative medicine in addressing SUI.