Related Experiment Video

Updated: May 21, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

MicroRNA involvement in lupus: the beginning of a new tale

Dong Liang1, Nan Shen

  • 1Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai Renji Hospital, Shanghai JiaoTong University School of Medicine, Chinese Academy of Sciences, Shanghai, China.

Current Opinion in Rheumatology
|June 27, 2012
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are increasingly recognized for their role in the development of Systemic Lupus Erythematosus (SLE). This review highlights their impact on SLE pathogenesis and therapeutic potential.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Autoimmune diseases like Systemic Lupus Erythematosus (SLE) involve complex pathogenic mechanisms.
  • MicroRNAs (miRNAs) are small non-coding RNAs with regulatory functions in gene expression.
  • Emerging evidence suggests miRNAs play a significant role in the pathogenesis of autoimmune disorders.

Purpose of the Study:

  • To review the current understanding of microRNA (miRNA) biology.
  • To explore the novel insights into Systemic Lupus Erythematosus (SLE) pathogenesis mediated by miRNAs.
  • To discuss the clinical relevance and therapeutic potential of miRNAs in SLE.

Main Methods:

  • Literature review of recent studies on miRNA biology and SLE.
  • Analysis of miRNA biogenesis and regulatory mechanisms.
  • Examination of miRNA expression signatures in SLE patients.

Main Results:

  • MiRNA biogenesis is a tightly regulated process influenced by various physiological and pathological factors.
  • MiRNAs are crucial for immune system development and function, and their dysregulation is linked to immunological disorders.
  • Distinct miRNA expression patterns in SLE indicate their involvement in disease pathogenesis and potential as biomarkers.

Conclusions:

  • MicroRNAs are actively involved in multiple facets of SLE pathogenesis.
  • Unique miRNA signatures in SLE highlight their importance in disease diagnosis.
  • MicroRNAs represent a promising target for novel therapeutic strategies in SLE.

More Related Videos

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...