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Updated: May 21, 2026
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Published on: January 26, 2024
Histopathological and immunohistochemical study of laterocervical lymph node metastases of unknown primary origin
Ramona Denise Mălin1, Elena Ioniţă, I Osman
1Department of ENT, University of Medicine and Pharmacy of Craiova, Craiova, Romania. ramona_denise@yahoo.com
Abstract:
In this study, we examined histopathologically and immunohistochemically 24 cases of laterocervical lymph node metastases with unknown primary origin. For immunohistochemical study, we used a large panel of antibodies represented by CK7, CK19, CK20, CKAE1/AE3, CK34betaE12, TTF1, HBME-1, CEA, MUC5AC and EBV. In the cases studied tumors accompanied by seemingly primitive adenopathies were located in the thyroid, lung, esophagus, stomach, rhinopharynx, hypopharynx, oropharynx and larynx.
