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Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers

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[Tetany secondary to deficiency rickets].

M del M Fernández Martínez¹, J L Gómez Llorente, M Martín González

¹Complejo Hospitalario Torrecardenas, Almería, España. marfm20@gmail.com

Nutricion Hospitalaria

|June 27, 2012

Summary

Hypocalcemia, a rare childhood illness, is increasing due to immigration. This case highlights vitamin D deficiency rickets, emphasizing the need for awareness in at-risk populations.

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Area of Science:

Pediatrics
Endocrinology
Nutritional Science

Background:

Rickets incidence has declined in developed nations but is rising due to immigration.
Etiology includes low sun exposure, poor diet, phytates, exclusive breastfeeding, and genetics.
Immigration contributes to increased rickets cases, particularly in children.

Observation:

A 13-year-old Pakistani immigrant presented with myoclonus, paresthesias, carpopedal spasm, and gait asymmetry.
Laboratory results revealed hypocalcemia, vitamin D deficiency (25(OH)D), and elevated parathyroid hormone.
Symptoms are consistent with severe nutritional rickets.

Findings:

Treatment with calcium, vitamin D, and dietary modifications normalized clinical and laboratory findings.
The case underscores the link between hypocalcemia, vitamin D deficiency, and rickets.
Successful management was achieved through supplementation and dietary changes.

Implications:

Increased migration necessitates heightened awareness of rickets in pediatric populations.
Public health strategies should address nutritional deficiencies and sun exposure in immigrant children.
Rickets, once declining, may re-emerge as a significant pediatric health concern globally.