Michael addition/pericyclization/rearrangement--a multicomponent strategy for the synthesis of substituted

Yu Liu1, Michael P Doyle

  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.