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Related Experiment Video

Updated: May 21, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin D intoxication.

Behzat Ozkan1, Sükrü Hatun, Abdullah Bereket

  • 1Department of Pediatric Endocrinology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.

The Turkish Journal of Pediatrics
|June 28, 2012
PubMed
Summary
This summary is machine-generated.

Vitamin D intoxication (VDI) is rising due to increased supplementation. Diagnosis requires checking 25-hydroxyvitamin D (25OHD) levels to prevent over-treatment and toxicity.

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Last Updated: May 21, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Toxicology

Background:

  • Vitamin D supplementation is increasing due to its recognized role in various diseases.
  • Vitamin D intoxication (VDI) is reported more frequently, linked to increased supplement intake.
  • Symptoms of VDI correlate with serum calcium levels and hypercalcemia duration.

Purpose of the Study:

  • To highlight the increasing incidence of Vitamin D intoxication (VDI).
  • To describe the clinical presentation and diagnostic criteria for VDI.
  • To outline treatment strategies for VDI and emphasize preventative measures.

Main Methods:

  • Review of clinical findings in Vitamin D intoxication.
  • Analysis of laboratory parameters including serum 25OHD, calcium, phosphorus, ALP, and PTH.
  • Description of treatment protocols for hypercalcemia and VDI.

Main Results:

  • VDI is characterized by hypercalcemia, high serum 25OHD (>150 ng/ml), low PTH, and high urine calcium/creatinine.
  • Severe hypercalcemia (>14 mg/dl) necessitates emergency intervention due to multi-organ risks.
  • Vitamin D's fat solubility can prolong toxicity effects for months.

Conclusions:

  • Misdiagnosis of vitamin D deficiency rickets (VDDR) can lead to unnecessary treatment and VDI.
  • Testing serum 25OHD and inquiring about prior vitamin D intake are crucial before initiating therapy.
  • Educating parents about safe supplementation practices is vital to prevent excessive vitamin D intake in infants.