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Isolation, synthesis, and evaluation of a series of indencarbazates as hypotensive agents
T L Lemke1, R Sanduja, M M Mroue
1Department of Medicinal Chemistry and Pharmacognosy, University of Houston, College of Pharmacy, TX 77204-5515.
Journal of Pharmaceutical Sciences
|September 1, 1990
Abstract:
Two indencarbazates, 1 and 2, were isolated from the sponge Cliona caribboea. These compounds were found to possess mild hypotensive activity. A series of analogues of 1 was synthesized in order to study the structure-activity relationship of this unique class of compounds. A variety of structural changes did not result in a consistent pattern of biological activity.