Quantitative spectroscopic photoacoustic imaging: a review
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Updated: May 21, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
Ben Cox1, Jan G Laufer, Simon R Arridge
1University College London, Department of Medical Physics and Bioengineering, Gower Street, London WC1E 6BT, United Kingdom. b.cox@ucl.ac.uk
Abstract:
Obtaining absolute chromophore concentrations from photoacoustic images obtained at multiple wavelengths is a nontrivial aspect of photoacoustic imaging but is essential for accurate functional and molecular imaging. This topic, known as quantitative photoacoustic imaging, is reviewed here. The inverse problems involved are described, their nature (nonlinear and ill-posed) is discussed, proposed solution techniques and their limitations are explained, and the remaining unsolved challenges are introduced.
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