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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Video

Updated: May 21, 2026

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
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Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

Asthma and ambient pollutants: a time series study.

Camila Trolez Amâncio1, Luiz Fernando Costa Nascimento

  • 1Departamento de Medicina, Universidade de Taubaté, Taubaté, SP, Brasil.

Revista Da Associacao Medica Brasileira (1992)
|June 28, 2012
PubMed
Summary

Exposure to air pollutants like particulate matter and sulfur dioxide significantly increases children's risk of asthma hospitalization in Brazil. This study highlights the health impacts of air quality in urban environments.

Area of Science:

  • Environmental Health
  • Pediatric Pulmonology
  • Epidemiology

Background:

  • Air pollution is a growing concern for public health, particularly in urban areas.
  • Pediatric asthma hospitalizations represent a significant healthcare burden.
  • Understanding the link between specific pollutants and respiratory exacerbations is crucial for targeted interventions.

Purpose of the Study:

  • To quantify the risk of asthma-related hospitalizations in children exposed to ambient air pollutants.
  • To investigate the association between specific air pollutants and pediatric asthma hospitalizations in a Brazilian city.

Main Methods:

  • Ecological time series study design.
  • Utilized hospitalization data for children under 10 and daily air pollutant concentrations (PM10, SO2, O3).

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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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  • Employed Poisson regression generalized additive models and Pearson correlation analysis.

    • Main Results:

    • Strong positive correlations observed between asthma hospitalizations and particulate matter (PM10) and sulfur dioxide (SO2).
    • Significant relative risks (1.01-1.04) of asthma hospitalization associated with PM10 and SO2 exposure on the same day and within three days.
    • Increased pollutant concentrations were linked to an 8-19% rise in hospitalization risk.

    Conclusions:

    • Air pollution demonstrably affects asthma hospitalization rates in children in medium-sized Brazilian cities.
    • Particulate matter and sulfur dioxide are identified as key contributors to increased asthma exacerbations requiring hospitalization.
    • Findings underscore the need for air quality management strategies to protect pediatric respiratory health.