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Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Cluster headache and parietal glioblastoma multiforme
Bengt Edvardsson1, Staffan Persson
1Department of Neurology, Faculty of Medicine, Lund University Hospital, Lund, Sweden. bengt.edvardsson@med.lu.se
The Neurologist
|June 28, 2012
Summary
Symptomatic cluster headache (CH) can be caused by a parietal glioblastoma. Enhanced MRI is crucial for diagnosing CH, even after a normal CT scan, especially in late-onset cases.
Area of Science:
- Neurology
- Oncology
Background:
- Cluster headache (CH) is typically a primary headache disorder.
- Symptomatic causes of CH are rare but documented.
- Diagnostic challenges persist in evaluating CH.
Observation:
- A 41-year-old male presented with severe, unilateral, orbital-temporal headaches.
- Symptoms included conjunctival injection and restlessness, mimicking CH.
- Initial brain CT was normal; diagnosis of CH was made.
Findings:
- Despite partial treatment response, enhanced MRI revealed a right parietal glioma.
- The glioma presented with edema and mass effect.
- Surgical debulking led to complete resolution of headache attacks.
Implications:
- Enhanced MRI is essential for CH evaluation, particularly with normal initial imaging.
- Late-onset CH warrants thorough investigation for underlying pathology.
- Parietal glioblastoma can manifest as cluster headache.
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