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Updated: May 21, 2026

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Published on: January 20, 2023
Postoperative global amnesia reversed with flumazenil
Joseph B Rinehart1, Brandee Baker, Darren Raphael
1Department of Anesthesiology and Perioperative Care, University of California, Orange, CA 92868, USA. jrinehar@uci.edu
Abstract:
Global postoperative amnesia (profound anterograde and retrograde amnesia) is rare and usually attributed to transient global amnesia-a poorly understood condition with no broadly accepted mechanism. We report an incident of probable transient global amnesia in a patient after endoscopic retrograde cholangiopancreatogram under general anesthesia, which was successfully treated with flumazenil. On the basis of the results of flumazenil administration in this and a previous case report, we would recommend a trial dose of 0.2 mg for cases of global postoperative amnesia, repeated if the first dose seems effective.
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