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Postoperative global amnesia reversed with flumazenil.
Joseph B Rinehart1, Brandee Baker, Darren Raphael
1Department of Anesthesiology and Perioperative Care, University of California, Orange, CA 92868, USA. jrinehar@uci.edu
The Neurologist
|June 28, 2012
Summary
Global postoperative amnesia, a rare condition causing memory loss after surgery, may be linked to transient global amnesia. This case suggests flumazenil may effectively treat such amnesia.
Area of Science:
- Anesthesiology
- Neurology
- Gastroenterology
Background:
- Global postoperative amnesia, characterized by profound anterograde and retrograde amnesia, is a rare complication.
- It is often attributed to transient global amnesia, a condition with an unclear underlying mechanism.
Observation:
- A patient developed probable transient global amnesia following an endoscopic retrograde cholangiopancreatogram performed under general anesthesia.
Findings:
- The patient's global postoperative amnesia was successfully treated with flumazenil.
- A low dose of flumazenil (0.2 mg) is proposed as a potential treatment, with repeat dosing if effective.
Implications:
- This finding suggests flumazenil as a potential therapeutic option for managing global postoperative amnesia.
- Further investigation into flumazenil's efficacy in treating transient global amnesia is warranted.
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